TP53 and gastric cancer: To some extent, similar findings on the prognostic significance of SMAD4 in GC were made in three Asian cohorts [49–51] and a two Caucasian cohorts [43, 52], however, with some differences and some major limitations: The number clinicopathological patient characteristics was limited in all preceding studies and none included resection, H. pylori, EBV, MSI, and p53 status [43, 49–52].