In addition, inhibitor of Aurora kinase B AZD1152-HQPA induces apoptosis in p53/p73 wild type U87MG glioblastoma cell line, whereas in p53/p73 double null SK-N-MC cells inhibition of Aurora kinase B leads to induction of cell cycle related genes, endoreplication and polyploidy, highlighting the role of p53/p73 [104, 201]. This evidence concerns the gene TP53 and glioblastoma.