CD4 and neoplasm: It was suggested that antigens from apoptotic tumor cells are phagocytized and processed by dendritic cells (DC) (professional antigen-presenting cells (APCs)) that migrate to regional lymph nodes and present the antigens to CD4 + T cells, that license the DCs to cross-present the antigens to cytotoxic CD8 + T cells that become activated and contribute to an anti-tumor immune response [18, 19].