TNF and brain injury: Moreover, Yang X found that stellate ganglion block may be involved in the regulation of neuroendocrine and immune system dysfunction in traumatic brain injury, the mechanism is to regulate NF- κ B protein, IL-1 β and TNF- α in lymphocytes through neuroendocrine immune system, CGRP, and inhibit the early excessive inflammatory reaction of traumatic brain injury, thus protecting the brain function of traumatic brain injury [51].