TP53 and nasopharyngeal carcinoma: Thus, the use of chemotherapy drugs such as cis-platinum that can not only induce DNA damage and p53/ATM activation (known activators of lytic EBV reactivation [71,73]), but can simultaneously degrade ΔNp63ɑ, is predicted to be the most effective approach for achieving efficient lytic induction therapy in EBV-positive NPC tumors.