Moreover, the methyl-CpG-binding protein, Mbd2, that acts to coordinate chromatin accessibility and hence, reprogramming of gene expression in response to DNA methylation, is key to the ability of DCs to drive Th2 responses to helminths and allergy [60] and also plays a role in CD11c+ DC/monocyte-epithelial cell crosstalk in gut inflammation [61]. This evidence concerns the gene MBD2 and allergic disease.