SOAT1 and rheumatoid arthritis: MicroRNAs (miRs) have been implicated in bridging JAK/STAT and MAPkinase signalling with epigenetic rewiring and consequent transcriptional reprogramming, with miR-146 and miR-155 proposed to be major species associated with SF pathogenesis in RA: indeed, both are elevated in fibroblast-like synoviocytes from RA patients (RA SFs) and have been associated with disease activity/severity [23–27].