Nowadays, not only the senile plaques (SPs) formed by deposition of amyloid-β protein [2] and neurofibrillary tangles (NFTs) formed by hyperphosphorylation of tau protein [3] were viewed as the characteristics of AD, but also the neuroinflammatory reaction participated by glial cells were viewed as the key pathological changes of AD [4]. Here, MAPT is linked to Alzheimer disease.