DLX4 and lung carcinoma: Tomida et al. have reported that enforced distal-less homeobox 4 (DLX4) gene expression, which is reduced in a highly metastatic lung cancer cell line and mostly associated with favorable prognosis in lung cancer patients, reduces lung cancer cell motility and invasion in vitro as well as their metastasis in vivo through both hematogenous and lymphogenous routes [54].