We have previously reported that both TG and TPO mRNA and protein are re-expressed in dedifferentiated thyroid cancer cells (NKX2-1−/PAX8+) infected with adenoviral vectors containing Nkx2-1 (AdNKX2-1), which induces radioiodide organification and retention [11]. The gene discussed is PAX8; the disease is thyroid gland carcinoma.