However, the present study identified a positive correlation between FOXP3+ cell density and viral load, negative correlation with blood CD4+, although not statistically significant, significant positive correlation in CD8 count in patients with leprosy reaction, positive relationship in patients with IRIS, and higher average density values of Treg cells in the clinical forms of TT/BT co-infection than in other clinical forms. The gene discussed is CD4; the disease is leprosy.