TAOK2 and Obesity: We did find a nominally significant burden of very rare coding variants in TAOK2 in people with severe obesity (n = 225 markers, p = 0.001, SKAT-O test; #case carriers = 14, #control carriers = 426, OR = 1.6 (0.9 to 2.8), p = 0.08, Fisher’s exact test) (S5 Table, S2 Fig). Analysis of the 2 specified regions of TAOK2 also indicated an association of rare variants in these regions with severe obesity (S5 Table, S2 Fig).