We did find a nominally significant burden of very rare coding variants in TAOK2 in people with severe obesity (n = 225 markers, p = 0.001, SKAT-O test; #case carriers = 14, #control carriers = 426, OR = 1.6 (0.9 to 2.8), p = 0.08, Fisher’s exact test) (S5 Table, S2 Fig). Analysis of the 2 specified regions of TAOK2 also indicated an association of rare variants in these regions with severe obesity (S5 Table, S2 Fig). This evidence concerns the gene TAOK2 and obesity due to melanocortin 4 receptor deficiency.