Similarly, inhibition of NAMPT, PARP, and AIFM1 reduced the transcript levels DEFB4 and S100A8, another inflammation marker associated with psoriasis (Fig 6B), while all treatments further reduced LOR and FLR mRNA levels, as did all-trans retinoic acid (ATRA) (Fig 6C). This evidence concerns the gene PARP1 and psoriasis.