In acid metabolism (hsa00410 beta-Alanine metabolism, hsa00380 tryptophan metabolism and hsa00340 histidine metabolism), Malonyl-CoA decarboxylase mitochondrial (MLYCD, O95822) and Aldehyde dehydrogenase mitochondrial (ALDH2, P05091) was up-regulated 2.200942237 and 2.745247991-fold respectively in central precocious puberty (Figure 7). The gene discussed is ALDH2; the disease is central precocious puberty.