To determine the effect of IRE1α activation on inflammation during C. rodentium infection, mice were intraperitoneally (i.p.)injected with the IRE1α inhibitor KIRA6 for the first 7 days of infection and then either sacrificed at day 7 or 10 postinfection or maintained until C. rodentium was cleared (Fig. 4A). This evidence concerns the gene ERN1 and infection.