Results of GSEA analysis demonstrated that immune response-related signaling pathways, including graft versus host disease (normalized enrichment score: 2.02, FDR = 0.007; Supplementary Figure 5) and allograft rejection (normalized enrichment score: 1.74, FDR = 0.024; Supplementary Figure 5) were significantly enriched in the top circuits of NLRP3 mutations. Here, NLRP3 is linked to glycogen storage disease VI.