Given the previous work that described how oxidative stress and the NRF2 regulator KEAP1 regulated IFNγ-mediated MHCII expression in human melanoma cells, NRF2 regulation and redox dysregulation could explain a possible mechanism for MED16 control of MHCII (Wijdeven et al., 2018). Here, KEAP1 is linked to melanoma.