NCR2 and inflammatory bowel disease: Inflamed tissues in IBD show marked reduction in IL-22 producing NKp44+ ILC3s and enhanced IFN-gamma producing potential of the ILC3 pool.110 This IBD-associated shift in the ILC3 pool accounts for persistent inflammation with deteriorating epithelial barrier integrity and regeneration, through the lack of regulatory mechanisms listed above (Figure 4c and Figure 4g).