GCG and inflammatory bowel disease: In the light of these observations, GLP-2 agonists have been studied as therapeutics in chemically or genetically induced murine IBD models and results are encouraging.99 Treatment with GLP-2 agonists had an anti-apoptotic and pro-proliferative action on crypt cells, resulting in increased crypt depth and villus height, decreased histological lesions, and increased intestinal weight and length.