ACLY and head and neck squamous cell carcinoma: We first obtained the gene expression and clinical data from The Cancer Genome Atlas (TCGA) database and then analyzed the ACLY expression in different types of cancers.[20] We found that ACLY mRNA levels were obviously elevated in tumor tissues compared with that in respective normal tissues in all eight solid tumors, including breast invasive carcinoma, colon adenocarcinoma, lung cancer, hepatocellular carcinoma, bladder urothelial carcinoma, head and neck squamous cell carcinoma, cervical cancer and stomach adenocarcinoma (Figure 1A).