ACLY and neoplasm: Citrate plays a crucial regulatory role in providing energy sources and maintaining energy homeostasis.[16, 45] However, reduced concentrations of citrate were observed in multiple tumor tissues and patient blood and could be an indicator of cancer aggressiveness and metabolic prognosis.[16] In the current study, we demonstrated overexpression of ACLY in cancer patients in various cancer types, which is negatively associated with clinical outcomes.