MAPK3 and neoplasm: Our previous studies also demonstrated that ERK1/2 and p38 MAPK signaling control the molecular process of human regulatory T cell (Treg) and tumor cell‐induced senescence in responder T cells.[29, 31, 33, 39, 42] Therefore, we reasoned that MAPK signaling may also be involved in citrate‐induced tumor cell senescence.