WWOX and neoplasm: Through its WW1 domain, WWOX physically interacts with several key signaling proteins (DVL, AP‐2, ErbB‐4, HIF1‐α, p53, p63, p73, c‐JUN, ITCH, and RUNX2) and suppresses tumor progression in several cancer cell types (Abu‐Remaileh et al, 2015).