Remarkably, targeted loss of Wwox function in rodent models (mice and rats) phenocopies the complex human neurological phenotypes, including severe epileptic seizures, growth retardation, ataxia, and premature death (Suzuki et al, 2009; Mallaret et al, 2014; Tanna & Aqeilan, 2018). Here, WWOX is linked to cerebellar ataxia.