Germline recessive mutations (missense, nonsense, and partial/complete deletions) in the WWOX gene were found to be associated with two major phenotypes, namely SCAR12 (spinocerebellar ataxia, autosomal recessive 12, OMIM 614322) and WOREE syndrome (WWOX‐related epileptic encephalopathy), the latter also known as developmental and epileptic encephalopathy 28 (DEE28, OMIM 616211) (Banne et al, 2021). Here, WWOX is linked to undetermined early-onset epileptic encephalopathy.