Furthermore, osteoblastic RCN1 contributed to proliferation and migration of NSCLC cells through suppressing ER stress that was associated with decreased GRP78, CHOP, IRE1α, p‐IRE1α, p‐PERK and p‐JNK, which could be positively regulated by self‐induced autophagy (Figure 5E). The gene discussed is EIF2AK3; the disease is non-small cell lung carcinoma.