Based on the positive and negative data, it is suggested that osteoblasts produced RCN1 into bone microenvironment and in turn transferred into NSCLC cells partially through encapsulating in EVs, leading to an increase in the RCN1 expression level in NSCLC cells, which facilitated proliferation and migration of NSCLC cells. The gene discussed is RCN1; the disease is non-small cell lung carcinoma.