Furthermore, osteoblastic RCN1 contributed to proliferation and migration of NSCLC cells through suppressing ER stress that was associated with decreased GRP78, CHOP, IRE1α, p‐IRE1α, p‐PERK and p‐JNK, which could be positively regulated by self‐induced autophagy (Figure 5E). This evidence concerns the gene HSPA5 and non-small cell lung carcinoma.