Also, some evidence from in-vitro rat models has shown that IGF-I might decrease the amount of α-crystallin (a lens protein) made in the lens fibre cells [46], therefore this might be expected to lead to a positive association of IGF-I with risk of cataracts since higher levels of α-crystallin have been associated with a lower risk of cataract formation [46]. Here, IGF1 is linked to cataract.