Similar associations were observed by sex-specific fifths of IGF-I concentration for these outcomes: carpal tunnel syndrome (HR in the top versus the lowest fifth = 1.34, 95% CI, 1.20–1.50), varicose veins (0.75, 0.64–0.87), cataracts (0.91, 0.87–0.95), diabetes (0.85, 0.79–0.91), and iron deficiency anaemia (0.77, 0.69–0.85) (Supplementary Table S2). The gene discussed is IGF1; the disease is Varicose veins.