TGFB1 and keratoconus: Conversely, elevated levels of TGFBIp have been found in areas of corneal scarring, likely due to TGFB1-mediated upregulation in response to corneal injury.126, 127, 128 Interestingly, two KC patients had stromal amyloid deposits that were associated with TGFBIp in the corneal buttons, but no TFGBI mutation was present.99