TTR and heart disorder: Prospective studies leveraging data with the ability to recontact patients to gather ongoing clinical phenotype data will be essential to developing appropriate surveillance and early treatment strategies in these individuals and their families, particularly given the clear impact of age on disease penetrance.PerspectivesCOMPETENCY IN MEDICAL KNOWLEDGE: Genetic variants in transthyretin, particularly the V122I variant, are associated with an increased risk of heart disease later in life.