ZPR1 and metabolic syndrome: Like APOE, ZPR1 also participates in lipid metabolism; it lies on chromosome band 11q23.3, and ZPR1 variant rs964184 has been consistently linked to high plasma triglyceride level, metabolic syndrome, T2DM, and NAFLD (Esteve-Luque et al., 2021; Fu et al., 2015; Gombojav et al., 2016; Guan et al., 2016; Mirhafez et al., 2016; Paquette et al., 2020).