Together with the protective effect of the GPER agonist G-1 against LV dysfunction and remodeling following ischemia-reperfusion, hypertension, high-salt diet or loss of estrogen (Deschamps and Murphy, 2009; Wang et al., 2012; Alencar et al., 2017; Bopassa et al., 2010; Filice et al., 2009; Jessup et al., 2010; Weil et al., 2010), these studies confirm the protective role of GPER1 in the heart. This evidence concerns the gene GPER1 and hypertensive disorder.