Also, ERβ or GPER1 activation opens L- and R-type voltage gated Ca2+ channels in hypothalamic neurons (Sun et al., 2010; Micevych and Christensen, 2012; Mermelstein, 2009) and GPER1 activation leads to IP3 generation in breast tumour cells (Qian et al., 2016; Szatkowski et al., 2010), so although GPER effects may be Ca2+-dependent, the mechanism may be different in different cell types. The gene discussed is GPER1; the disease is breast neoplasm.