However, for inherited forms of ALS such as C9ORF72 repeat expansions (C9) there were specific changes in neuronal activity, gene expression, and cellular processes (Devlin et al., 2015; Donnelly et al., 2013; Sareen et al., 2013; Selvaraj et al., 2018; Shi et al., 2018; Wainger et al., 2014). Here, C9 is linked to amyotrophic lateral sclerosis.