Peaks that were less accessible in C9-ALS samples were enriched for several TFs including Nuclear Factor I (NF1) family that controls the onset of gliogenesis in the developing spinal cord (Deneen et al., 2006) and LIM Homeobox (LHX) TFs that regulate expression of axon guidance receptors (Palmesino et al., 2010) (Figure 3A). Here, NF1 is linked to amyotrophic lateral sclerosis.