One open trial with 73 patients studied caregiverreported outcomes in multi-infarct dementia, but the outcomes ofinterest for our analysis were not evaluated.124 A recent Cochrane review performed network meta-analysis oftrials using cholinesterase inhibitors (including the Narasimhalu trialof a post-stroke population) and found varying quality evidence thatdonepezil and galantamine may improve cognition compared to placebo, butthe effect may not be sufficiently large to be clinically important.125 There was low certainty evidence that rivastigmine had nosignificant effect on cognition. This evidence concerns the gene BCHE and multi-infarct dementia.