The Schwachman-Bodian-Diamond syndrome (Sbds) gene was expressed at significantly lower levels in the osteo-lineage cells after Dicer1 disruption, and deletion of Sbds in osterix+ osteoprogenitors produced leukopenia, lymphopenia, and myelodysplasia, recapitulating key features of Dicer1 deficiency in the same cells[39]. This evidence concerns the gene SBDS and Decreased total leukocyte count.