STAT3 and familial pancreatic carcinoma: For instance, Xie et al. suggested that exosomal miR-193a-3p derived from hypoxic BMSCs could promote lung cancer cell invasion through regulation of STAT3 and the EMT process [38]; Wu et al. showed that exosomal miR-126 derived from BMSCs could inhibit the tumorigenesis of pancreatic cancer through targeting ADAM9 [39].