Individuals who develop T2DM usually show excessive adipogenesis, nuclear peroxisome proliferator-activated receptor modulation, insulin resistance, hyperinsulinemia, pancreatic β-cell stress, progressive reduction of insulin secretion, impaired glucose postprandial, and fasting glucose levels [78], and the phytoconstituents present in the Nymphaea species so far are reported to control the damage via an impaired glucose mechanism (Figure 3). This evidence concerns the gene INS and Insulin resistance.