The hub components may be quercetin, stigmasterol, kaempferol, and beta-sitosterol, and probably through pairing core targets such as AKT1, VEGFA, and IL6, to regulate neuronal death, G protein-coupled amine receptor activity, reactive oxygen species metabolic processes, membrane rafts, MAPK signaling pathways, and cellular senescence that can play a role in the treatment of PD. This evidence concerns the gene IL6 and Parkinson disease.