In our study, with the differential analysis of microarray data from the GEO database, 11 cell cycle-related key genes (RRM2, NDC80, ECT2, CCNB1, ASPM, CDK1, PRC1, KIF20A, DTL, TOP2A, and PBK) involved in the process of the transition from liver cirrhosis to carcinoma were identified. Here, RRM2 is linked to carcinoma.