After recoding all parametrical characterized parameters into nominal variables, based on their individual median (fasting insulin recoding based on the definition for hyperinsulinemia), all identified risk factors remained significant for predicting increased IMT {RR: mean [95% CI] (BMI: 1.5 [1.2, 2.1]; age: 1.7 [1.3, 2.1]; smoking: 2.0 [1.4, 2.8]; hyperinsulinemia: 1.8 [1.3, 2.4])} or arteriosclerosis {RR: (BMI: 1.8 [1.5, 2.2]; sex: 1.9 [1.5, 2.3]; smoking: 2.2 [1.7, 2.9]; hyperinsulinemia: 2.5 [2.0, 3.2])} as shown before in the logistic regression analyses. The gene discussed is INS; the disease is Hyperinsulinemia.