The rearranged 16; 21 chromosomes within AML cells contribute to forming the TLS/FUS-ERG fusion gene, owing to which patients are resistant to conventional chemotherapy (Kong et al., 1997), and FUS has a certain effect on the development of APL cell resistance to retinoic acid as a consequence of mutations in the binding domain (Walsby et al., 2007). The gene discussed is ERG; the disease is acute myeloid leukemia.