Matsuo et al. reported that the PI3K/Akt pathway was activated by FN with the aid of integrin αv-mediated a disintegrin and metalloprotease (ADAM) activity in hepatocellular carcinoma (Matsuo et al., 2006), providing us with a new understanding of the PI3K/Akt pathway in FN-related tumor progression. Here, FN1 is linked to hepatocellular carcinoma.