CEACAM5 and colorectal carcinoma: In the univariate regression analysis, we found that the DIR.LDH, lymph node ratio, differentiation, TNM stage, circumferential margin, vascular cancer embolus, nerve infiltration, and CEA and CA199 levels might be independent prognostic factors for DFS and OS, and we included the above indicators in the multivariate regression analysis and found that DIR.LDH was indeed an independent prognostic factor for patients with CRC (Table 2).