In the training cohort, the C-index of the prognostic model for OS based on age, sex, TNM stage, circumferential margin status, vascular cancer embolus status, nerve infiltration status, differentiation, DIR.LDH, lymph node ratio, location, CEA and CA199 levels was 0.802 (95% CI, 0.76–0.85). The gene discussed is CEACAM5; the disease is vascular cancer.