Moreover, Hanieh, (2015; 2016) assessed the AhR-miR-212/132 axis in breast cancer cell lines and confirmed the anti-metastatic properties of the miRNA cluster through suppression of SOX-4, which inversely is a pro-metastatic factor and has binding sites for miR-212/132 on the 3′ UTR region. This evidence concerns the gene SOX4 and breast carcinoma.