Donate et al. (2021) found that cigarette smoke activates the AhR on Th17 cells directing the up-regulation of miR-132, which is then packaged into extracellular vesicles that induce osteoclastogenesis via the suppression of COX-2 that catalyzes prostaglandins. Rogers et al. (2017) also investigated the AhR-dependent regulation of pulmonary miRNAs by chronic cigarette smoke exposure and they have shown that AhR reduced the levels of miR-96, which is a potent suppressor of inflammation and strongly implicated in cancer progression. Here, AHR is linked to cancer.