Our previous research screened four genes from ENZ-resistant C4-2B cells, which were CCNA2, CKAP2L, NCAPG, and NUSAP1, and confirmed that the protein levels of these four genes also remained higher in ENZ-resistant xenograft tumor tissues (Feng et al., 2021a; Feng et al., 2021b). This evidence concerns the gene CKAP2L and neoplasm.