PNPLA3 and fatty liver disease: Bellan et al. studied the impact of PNPLA3 rs738409 SNPs in the prediction of hepatic steatosis and fibrosis in a cohort of 328 patients from the Northern Italy and found that the carriage of the G allele was associated with higher liver stiffness values (5.9 kPa in CC homozygotes, 6.1 kPa in CG heterozygotes, and 6.8 kPa in GG homozygotes; p = 0.01), whereas no differences were found in glycated hemoglobin in the subgroups by the genotypes (23).