The impact of PNPLA3 polymorphisms on the onset and severity of liver disease in the subgroup of the patients with diabetes was also investigated; however, the strength of this association was irrelevant and the authors concluded that confounding factors, such as body mass index (BMI), could play a major role in the development of liver disease in the diabetic population (23). This evidence concerns the gene PNPLA3 and diabetes mellitus.