TM6SF2 and Hepatic fibrosis: For example, the single nucleotide polymorphisms (SNPs) in phospholipase domain-containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2) gene have been recently associated with the development of steatosis, NAFLD-related hepatocellular carcinoma (HCC), and the stage of liver fibrosis (6–8).