In conclusion, our findings suggest that in diabetic population, the GG genotype of PNPLA3 rs738409 and the CC genotype of KLF6 rs3750861 SNPs are associated with the higher stiffness values and the risk of developing liver fibrosis, whereas the CC genotype of SOD2 rs4880 and the CT genotype of KLF6 rs3750861 SNPs are associated with the lower eGFR values. The gene discussed is KLF6; the disease is Hepatic fibrosis.