In multiple logistic regression analysis, apart from presence of DM as well as serum albumin and CRP values, the percentages of the CD14++CD16+ monocytes and the Tregs were significantly associated with the presence of ACVD; increase of CD14++CD16+ up to 1% was associated with 31% less risk for ACVD (OR 0.69; 95% CI, 0.48–0.98; p = 0.041) and increase of Tregs up to 1% was associated with 20 times higher risk for ACVD (OR 20.5; 95% CI, 1.5–274.7; p = 0.022). The gene discussed is ALB; the disease is diabetes mellitus.