MAPT and Alzheimer disease: The currently recognized strategies for the clinical diagnosis of AD mainly include (1) brain imaging such as positron emission tomography (PET) for measuring brain amyloidosis and tauopathies, magnetic resonance imaging (MRI) for measuring medial temporal atrophy, and fluorodeoxyglucose positron emission tomography (FDG-PET) for measuring low glucose metabolism; (2) measurement of cerebrospinal fluid (CSF) biomarkers, such as Aβ42 and phospho-tau levels (Bocchetta et al., 2015); and (3) different types of neuropsychiatric tests, such as Mini Mental State Examination (MMSE).