After adjustment for age, sex, hypertension, hyperlipidemia, CHD, family history of diabetes, diabetes duration, HbA1c, insulin treatment, and diabetic complications, no significant change was observed: the ORs and 95% CIs for MCI were 1.00 (ref.), 2.32 (0.95–5.65), 2.80 (1.18–6.67), 3.53 (1.52–8.19), and 2.13 (1.39–3.28), with p trend = 0.007. The gene discussed is INS; the disease is diabetes mellitus.