DMRs analysis highlighted an enrichment of pathways linked to cellular components between all psoriasis patients and healthy controls, including the Small nuclear ribonucleoprotein (snRNP) complex, for which a class of autoantigens known as RNA-associated molecules and autoantibodies recognizing snRNPs has been described in a variety of autoimmune/inflammatory diseases, including systemic lupus erythematosus (SLE), systemic sclerosis and mixed connective tissue disease (Kattah et al., 2010). This evidence concerns the gene LSM2 and mixed connective tissue disease.