Increasing studies about the association between ferroptosis and the TIME have been performed since the term ferroptosis was coined in 2012, and most of these studies demonstrated that ferroptosis might contribute to the immune surveillance and cytotoxic effects of CD8+ T cells (Wang et al., 2019), while others reported that ferroptosis facilitated the formation of a tumor-promoting immune microenvironment (Wen et al., 2019). The gene discussed is CD8A; the disease is neoplasm.