PHYHIPL and colon adenocarcinoma: Similarly, AL161772.1-has-miR-106a-5p-TNFSF11 and AC124067.4-hsa-miR-92b-3p(hsa-miR-589-5p)-PHYHIPL both reduce the TMB and MSI in COAD, decreasing the risk of alterations and genome instability.