Two hotspots for ALS-linked mutations in FUS are within its nuclear localization sequence, resulting in the accumulation of FUS in the cytoplasm (Vance et al., 2013), and the N-terminal intrinsically disordered region (IDR), promoting aggregation (Murakami et al., 2015; Patel et al., 2015). This evidence concerns the gene FUS and amyotrophic lateral sclerosis.