VHL and nonpapillary renal cell carcinoma: Indeed, the downregulation of oxygen consumption rate (OCR) and OXPHOS is a well-characterized feature of VHL inactivated ccRCC cells, and is partially buffered by the metabolic rewiring of ccRCC cells by constitutive activation of the hypoxia-inducible factor (HIF) pathway (Nilsson et al., 2015; Briston et al., 2018).