Genetic models: DISC1, RELN, CLU3 and ATX, PGC-1α–/–, 22q11.2 1.5 Mb deletion [Df(16)A ± ], NL2 R215H knock-in mouse model of schizophrenia suggested alterations of E-I balance. The gene discussed is ENPP2; the disease is schizophrenia.