RELN and psychiatric disorder: Similarly, impaired maturation and refinement of glutamatergic and GABAergic synaptic transmissions in the postnatal PFC were found in mice with reelin haploinsufficiency, which ultimately impacted the sequence of synaptic E-I balance development, and therefore, provides a potential mechanism for altered E-I balance in the prefrontal circuit in patients with psychiatric disorders (Bouamrane et al., 2016).