SYNGAP1 and Cognitive impairment: Studies have demonstrated that Syngap1 haploinsufficiency in mice caused profound core features of schizophrenia, such as hyperactivity, decreased prepulse inhibition, impaired working and spatial reference memory (Guo et al., 2009; Nakajima et al., 2019), generalized cortical excitability (Ozkan et al., 2014), and abnormal gamma oscillation (Berryer et al., 2016), whereas supplementation of the Syngap1 protein can reverse or attenuate the manifestation of behavioral problems, cognitive deficits and medically refractory seizures (Vazquez et al., 2004; Aceti et al., 2015).