ESR1 and neoplasm: To better understand the potential roles of PGRMC1 expression in breast cancer, we initially analyzed the ex-pression of PGRMC1 at transcript level in breast cancer patient cohort retrieved from the TCGA-BRCA and METABRIC dataset We found that PGRMC1 was associated with tumor subtypes, patient age, estrogen receptor (ER) status, progesterone receptor (PR) status and Her2 status.