TIMP1 and obesity due to melanocortin 4 receptor deficiency: Also, macrophage marker (F4/80), a marker of inflammation (TNF-α), a marker of tissue fibrosis, collagen-1 (Col1a), and tissue inhibitor of metalloproteinase-1 (Timp1) increase in the adipose deposits of 20-week old offspring mice exposed to HFD from obesity-resistant (OR) mothers (124).