Our previous study also found that the Ku70-mediated type-III IFN response was induced in an HSV-1 strain-dependent manner: Infection with the HSV-1 McKrae strain triggers the cytoplasmic translocation of Ku70 and induces IFN-λ1 induction, while infection with the HSV-1 MacIntyre strain does not. This evidence concerns the gene XRCC6 and infection.