Although the T allele of ACE2 rs2106809 has been shown to be inversely correlated with severe malaria (De et al., 2021), accumulating evidence suggests that most ACE2 polymorphisms could lead to a variety of diseases, such as atrial fibrillation, hypertension, type 2 diabetes mellitus (T2D), cardiomyopathy and so on. This evidence concerns the gene ACE2 and atrial fibrillation.